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Research Done on Albion Chelates

Albion Human Nutrition values research into product effectiveness, mineral availability, and use. Albion provides product to third party organizations that conduct their own research and studies and then come to their own conclusions. We also carry out our own sponsored research and clinical studies.

Albion has over 123 published research papers involving Albion’s chelated minerals, mineral absorption, and the effects of our chelated minerals on different functions of the body. We also have many research studies that are as yet unpublished due to proprietary finds that may later be developed into patents. With over 150 patents, our Science & Research division is continuously working on new concepts and researching ways to make mineral delivery systems better for you, the consumer.

Below are just a few research summaries. More will be added and removed in the future so please return to this page often.

Zn Bisglycinate vs. Zn Gluconate After a Single Administration to Twelve Healthy Female Volunteers

Gandia P, Bour D, Maurette J, Donazzolo Y, Duchene P, Bejot M, and Houin G.
Int. J. Vitam. Nutr. Res., 77(4), 243-248

This study compared the oral bioavailability of Albion’s zinc bisglycinate chelate with zinc gluconate in a randomized cross-over study in 12 female volunteers. Study results show that zinc chelate was safe and well tolerated. Compared with the gluconate, the oral bioavailability of zinc chelate was 43.4% more bioavailable.

Comparison of calcium absorption from various calcium-containing products in healthy human adults: A bioavailability study

Mukherjee R, McCorquodale M, Crowley D, Ashmead S, and Guthrie N.
The FASEB Journal 10:A1063-A1064

Supplementation with various calcium preparations is now the most common approach to increase calcium intake in individuals concerned with osteoporosis. However, it has been shown that the bioavailabilities of many commercial calcium preparations are different. This study compared the bioavailability of calcium after supplementation with four preparations: Albion’s di-calcium malate, Albion’s calcium chelate containing 18% calcium, calcium chelate containing 26% calcium, and industry standard calcium carbonate. Based on the results of this study, di-calcium malate seems to be the most bioavailable compared to the other supplements being investigated with a longer half life. The two calcium chelates were the next most bioavailable of the four followed by calcium carbonate.

The nutritional benefits and safety of minerals which have been chelated with amino acids

Jeppsen RB, Bourdonnais A, Ashmead HD
Proceedings 6th International Symposium on Chelating Agents in Pharmacology, Toxicology and Therapeutics

Minerals are essential to life, but cannot be manufactured by life. All minerals must be absorbed into the body from the outside. Inorganic sources of minerals can cause to irritation of the gastrointestinal tract in nutritional quantities and irritation or toxicity when larger doses of the mineral may be required for specific nutritional needs. Supplementing diets with inorganic minerals also causes mineral interactions, which suppress rates of absorption. Albion’s minerals chelated with amino acids have shown greater bioavailability and utilization in humans. Less irritation has been indicated in human studies from ingesting our minerals as metal amino acid chelates.

Effectiveness of Iron Amino Acid Chelate on the Treatment of Iron Deficiency Anaemia in Adolescents

Pineda O, Ashmead HD, Perez JM, and Lemus CP
Journal of Applied Nutrition, Volume 46, Numbers 1 & 2

In this study, the tolerability of supplemental iron in the chelated form of Albion’s Ferrochel® was compared to ferrous sulfate in a randomized, double-blind, cross-over trial. Of the 38 women evaluated, 37% experienced moderate-to-severe side-effects with symptoms of bloating, constipation, and nausea while taking the sulfate formulation. However, only 21% of participants experienced some of these symptoms while taking the chelate formulation. The remaining study participants had the same symptom profile with both preparations. A significant number of women preferred the chelate to the sulfate formulation because of the lower number of side effects experienced with the Albion chelate.

Bioavailability of Magnesium Bisglycinate vs Magnesium Oxide in Patients with Ileal Resection

Schuette S, Lashner B, Du F, and Janghorbani M
Journal of Parenteral and Enteral Nutrition, Vol. 18, No. 6

Patients who have undergone ileal resection are at risk for developing magnesium depletion/deficiency. Magnesium repletion is difficult to accomplish because of the laxative effect of most oral magnesium supplements at therapeutic doses. The results of in vitro and in situ studies show that Albion’s magnesium chelate represents a highly available form of magnesium. Data from this study support the suggestion that some portion of magnesium chelate is absorbed intact, probably through a dipeptide transport pathway. Albion’s magnesium bisglycinate chelate may be a good alternative to commonly used magnesium supplements in patients with intestinal resection.

Milk Inhibits and Ascorbic Acid Favors Ferrous Bisglycinate Chelate Bioavailability in Humans

Olivares M, Pizarro F, Pineda O, Name J, Hertrampf E, and Walter T.
J Nutr. 1997 Jul; 127(7):1407-11

In this study, the bioavailability of Albion’s iron bisglycinate chelate [Ferrochel®] added to water and milk was studied using a double-isotopic method in two groups of 14 women. The findings show that milk and ascorbic acid affect Ferrochel® bioavailability. The findings also demonstrate that iron stores may influence Ferrochel's bioavailability as well. The researchers concluded that good bioavailability of Albion’s Ferrochel® makes this compound a suitable alternative to be considered in iron fortification programs.

Absorbability of Calcium Sources: The Limited Role of Solubility

Robert P. Heaney, Robert R. Recker, and Connie M. Weaver.
Center for Hard Tissue Research, Creighton University, Omaha, Nebraska: and Department of Foods and Nutrition, Purdue University, West Lafayelte, Indiana. USA.

This study looks at the relationship between calcium solubility and absorption, listing seven calcium sources.  Two of the sources used were Albion products: CCM (calcium citrate malate) and calcium bisglycinate chelate. The other calcium sources were three found naturally in foods and two other popular forms found commercially: calcium carbonate and calcium citrate.  This study is the result of 352 studies on human subjects and collated data from several years of absorption protocols.

Vitamin Angel graphic.

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